Adolescent Drinking Increases Anxiety, Alcohol Abuse Later in Life

*The following is excerpted from an online article posted on EurekAlert.

Adolescent binge drinking modifies gene expression in a fashion that increases susceptibility to anxiety and alcohol use disorders in adulthood, according to research in rats recently published in eNeuro. Targeting the microRNAs responsible could be a new route for undoing the damage of alcohol use caused during adolescence.

Previous researchers found that microRNA, small bits of RNA that modify how genes are expressed rather than coding for a protein, are involved in how early-life alcohol exposure changes the brain, but the exact mechanism was unknown.

Researchers exposed adolescent rats to alcohol and measured the resulting levels of miR-137, one type of microRNA, in the rats’ amygdalae. The rats exposed to alcohol displayed increased levels of miR-137, resulting in lower expression of proteins necessary for healthy neuron growth and branching.

In adulthood, the rats displayed higher levels of anxiety behaviors and a higher preference for alcohol compared to control rats. Inhibiting miR-137 in the amygdala reversed the anxiety and alcohol preference in the rats with an adolescent drinking history.

Source: EurekAlert!
https://www.eurekalert.org/pub_releases/2019-11/sfn-adi111219.php

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[reposted by] Jim Liebelt

[reposted by] Jim Liebelt

Jim is Senior Writer, Editor and Researcher for HomeWord. Jim has over 35 years of experience as a youth and family ministry specialist, having served over the years as a pastor, author, consultant, mentor, trainer, college instructor, and speaker. Jim’s HomeWord culture blog also appears on Crosswalk.com and Religiontoday.com. Jim and his wife Jenny live in Quincy, MA.

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